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In Crohn's disease (CD), two meta-analyses showed that dapsone was more effective than placebo, although its efficacy was not superior to that of immunosuppressants. The available data on its efficacy in CD are limited, and the decision to use dapsone for CD should be made on an individual basis. In CD, the safety of dapsone has been established by a randomized controlled trial. The side effects of dapsone are mild and rarely cause discontinuation of the therapy. There is some evidence for the beneficial effect of dapsone on steroid-resistant inflammatory bowel disease, but further studies are needed.Delivery of a time-varying plasma-derived coagulation factor concentrates by albumin dialysis: a prospective, randomized study. Plasma-derived coagulation factor concentrates are now available with a new approach to manufacture in which the factor is concentrated and purified in a purified albumin-dextrose solution. 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